
The Islamic State group said on social media it had carried out the attack.
The shrine, which is highly revered by Shia Muslims, has been targeted before, most recently in February last year.
The attack happened as the government and opposition groups gathered in Geneva in a bid to start talks aimed at a political solution to the conflict.
While both sides are in Geneva, the talks have yet to begin - the main opposition group says the Syrian government must first meet key humanitarian demands.
US Secretary of State John Kerry urged both sides to seize the opportunity to end the bloodshed.
Mr Kerry said there was "no military solution" to the spiralling crisis, which he warned could engulf the region if the tentative UN-sponsored negotiations fail as previous attempts have.
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